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4-Aminopyrimidine is a useful building block in preparation of several anticancer agents. Analogs have shown inhibition of PI3K/Akt/mTOR kinase pathway, inhibiting breast cancer cell growth within a murine model. Additional analogs have shown good potency as anti-Alzheimer’s agents with ability to cross the blood-brain barrier. The analogs have good bioavailability in addition to potential microbial activity.
| Cas No. | 591-54-8 |
|---|---|
| Purity | ≥98% |
| Formula | C4H5N3 |
| Formula Wt. | 95.11 |
| Synonym | 4-Pyrimidinamine, 4-Pyrimidineamine, 6-Aminopyrimidine |
| Melting Point | 154-156°C |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
Xiao Y, Huck B, Lan R, et al. Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors. Bioorg Med Chem Lett. 2021 Oct 15;50:128352. PMID: 34481987.
Xu X, Lu P, Wang J, et al. Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors. Chem Biol Drug Des. 2019 May;93(5):926-933. PMID: 30667164.
Fukuda T, Ishiyama T, Katagiri T, et al. Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: design and optimization of novel 4-aminopyrimidine derivatives. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337. PMID: 30217414.
Rembold H. [Inhibition of Crithidia growth by 4-aminopyrimidine]. Hoppe Seylers Z Physiol Chem. 1964;339(1):258-259. PMID: 5829233.