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4-Aminopyrimidine

Product ID A016493
Cas No. 591-54-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $70.90 In stock
1 g $136.30 In stock
5 g $408.80 In stock
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  • Description
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Description

4-Aminopyrimidine is a useful building block in preparation of several anticancer agents. Analogs have shown inhibition of PI3K/Akt/mTOR kinase pathway, inhibiting breast cancer cell growth within a murine model. Additional analogs have shown good potency as anti-Alzheimer’s agents with ability to cross the blood-brain barrier. The analogs have good bioavailability in addition to potential microbial activity.

Product Info

Cas No.

591-54-8

Purity

≥98%

Formula

C4H5N3

Formula Wt.

95.11

Synonym

4-Pyrimidinamine, 4-Pyrimidineamine, 6-Aminopyrimidine

Melting Point

154-156°C

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

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References

Xiao Y, Huck B, Lan R, et al. Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors. Bioorg Med Chem Lett. 2021 Oct 15;50:128352. PMID: 34481987.

Xu X, Lu P, Wang J, et al. Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors. Chem Biol Drug Des. 2019 May;93(5):926-933. PMID: 30667164.

Fukuda T, Ishiyama T, Katagiri T, et al. Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: design and optimization of novel 4-aminopyrimidine derivatives. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337. PMID: 30217414.

Rembold H. [Inhibition of Crithidia growth by 4-aminopyrimidine]. Hoppe Seylers Z Physiol Chem. 1964;339(1):258-259. PMID: 5829233.

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