Description
C-82 is an active metabolite of PRI-724 adn is an inhibitor of beta-catenin. Endometriotic cyst stromal cells treated with C-82 in vitro showed inhibited cell growth, cell migration, and fibrosis.
Product Unit Size | Cost | Quantity | Stock |
---|
C-82 is an active metabolite of PRI-724 adn is an inhibitor of beta-catenin. Endometriotic cyst stromal cells treated with C-82 in vitro showed inhibited cell growth, cell migration, and fibrosis.
Cas No. | 1422253-37-9 |
---|---|
Purity | ≥99% |
Formula | C33H34N6O4 |
Formula Wt. | 578.67 |
IUPAC Name | (6S,9S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide |
Synonym | C 82, C82 |
Appearance | White crystalline powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Hirakawa T, Nasu K, Miyabe S, et al. beta-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis. Sci Rep. 2019 Dec 27;9(1):20056. PMID: 31882904
Lafyatis R, Mantero J, Gordon J, et al. Inhibition of beta-catenin signaling in the skin rescues cutaneous adipogenesis in systemic sclerosis: a randomized, double-blind, placebo-controlled trial of C-82. J Invest Dermatol. 2017 Dec;137(12):2473-2483. PMID: 28807667
Cyclic peptide; calcineurin inhibitor.
Aminoglycoside; protein translation inhibitor.<...
Endogenous catecholamine precursor, also found ...
Endogenous neurotransmitter; GABA agonist.
Phenol found in various fruits; HDAC modulator....
MEK1/2 and ERK inhibitor.
Galactose-derived hexosamine sugar, component o...
Nicotinic acid derivative; InhA inhibitor.
FIASMA, 5-HT3 and σ1 agonist, SERT inhibitor.<...
GSK3 and AChE inhibitor, potential σ1 agonist....
Endogenous anionic non-sulfated glycosaminoglyc...
MEK1/2 inhibitor.
Protease inhibitor.
SERT inhibitor.
Endogenous sphingolipid involved in cell signal...
Flavonoid glycoside found in Pyrola.
α3β2, α3β4, α4β2 nAChR antagonist, indire...
STING inhibitor
Inhibitor of tropomyosin kinase receptors TRKA,...
Oxyindole alkaloid found in Uncaria sinensis; h...