• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nitidine Chloride

Nitidine Chloride

Product ID N3577
Cas No. 13063-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $91.00 In stock
5 mg $145.80 Please Inquire
25 mg $592.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), inhibiting cellular migration and invasion. In vivo, nitidine inhibits activation of JAK/STAT3, downregulates expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl-2, and upregulates expression of p21 and Bax, resulting in decreases in tumor weight and volume. Additionally, nitidine inhibits topoisomerase I and binds to DNA sequences containing alternating G and C base pairs. In macrophages, this compound decreases production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and inhibits phosphorylation of MAPK and activation of NF-κB. Nitidine also displays inhibitory activity against species of Plasmodium that are resistant to chloroquine and other antimalarial compounds.

Product Info

Cas No.

13063-04-2

Purity

≥98%

Formula

C21H18ClNO4

Formula Wt.

383.82

IUPAC Name

2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

Solubility

1mg/ml in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N3577 MSDS PDF

Info Sheet

N3577 Info Sheet PDF

References

Fang Z, Tang Y, Jiao W, et al. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. PMID: 23911800.

Liao J, Xu T, Zheng JX, et al. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. Int J Mol Med. 2013 Jul;32(1):79-84. PMID: 23613111.

Wang Z, Jiang W, Zhang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. PMID: 22971898.

Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.

Nyangulu JM, Hargreaves SL, Sharples SL, et al. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10. PMID: 15808457.

Li D, Zhao B, Sim SP, et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. PMID: 12538017.

Del Poeta M, Chen SF, Von Hoff D, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8. PMID: 10582872.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T3461

    Tiplaxtinin

    PAI-1 inhibitor.

    ≥98%
  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • N1976

    Netilmicin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • C9660

    Cypermethrin

    Synthetic type II pyrethroid insecticide; prote...

    ≥95%
  • I058584

    Ibotenic Acid

    Analog of glutamate

    ≥98%
  • T1750

    Temocapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • C016481

    Camalexin

    Phytoalexin

    ≥98%
  • T6903

    Tranylcypromine Hydrochloride

    MAO and histone demethylase LSD1 inhibitor.

    ≥98%
  • R8178

    Rutaecarpine

    Indoloquinazoline alkaloid found in Evodia; COX...

    ≥98%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • N3496

    Nizatidine

    Histamine H2 inverse agonist.

    ≥98%
  • D1731

    15,16-Dehydrocafestol

    Diterpene found in roasted coffee.

    ≥98%
  • O0400

    Obatoclax

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥98%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-...

    ≥98%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • L5658

    Lonidamine

    Hexokinase inhibitor, aerobic glycolysis inhibi...

    ≥98%
  • A4000

    AK-1

    SIRT2 inhibitor.

    ≥99%
  • M1749

    Memantine Hydrochloride

    D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist.<...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only