Memantine Hydrochloride

Name: Memantine Hydrochloride
SKU: M1749
Availability: InStock

Product ID M1749

Cas No. 41100-52-1

Purity ≥97%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Memantine is an inhibitor of NMDA receptors that exhibits neuroprotective and cognition enhancing activities and is clinically used to treat Alzheimer’s disease, dementia, and Parkinson’s disease. Memantine also inhibits 5-HT3 receptors and α7 nicotinic acetylcholine receptors (nAChRs) and activates D2 receptors. Memantine improves spatial learning and memory impairments in various animal models and clinical settings. Additionally, memantine stimulates dendritic spine maturation and synapse formation in vivo.

Product Info

Cas No.	41100-52-1
Purity	≥97%
Formula	C₁₂H₂₁N • HCl
Formula Wt.	215.77
Chemical Name	3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
IUPAC Name	3,5-dimethyladamantan-1-amine;hydrochloride
Synonym	Akatinol
Melting Point	258°C
Solubility	Soluble in water.
Appearance	White or off-white crystals or crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M1749 MSDS PDF
Info Sheet	M1749 Info Sheet PDF
Brochure	Memantine Flyer

References

Liu MY, Wang S, Yao WF, et al. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience. 2014 Jul 25;273:141-51. PMID: 24846616.

Wei H, Dobkin C, Sheikh AM, et al. The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome. PLoS One. 2012;7(5):e36981. PMID: 22615862.

Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2009 Jul;8(7):613-8. PMID: 19520613.

Seeman P, Caruso C, Lasaga M. Memantine agonist action at dopamine D2High receptors. Synapse. 2008 Feb;62(2):149-53. PMID: 18000814.

Aracava Y, Pereira EF, Maelicke A, et al. Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. PMID: 15522999.

Rammes G, Rupprecht R, Ferrari U, et al. The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner. Neurosci Lett. 2001 Jun 22;306(1-2):81-4. PMID: 11403963.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Memantine Hydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

SAR245409

(R)-P7C3-OMe

Neuromedin B, pig

Splitomicin

Clonidine Hydrochloride

Didymin

Recombinant M. Tuberculosis Antigen TB 38+6+10

SR-717 Lithium Salt

Methylisoindigotin

Vesicular Stomatitis Virus Peptide

Benzyl Analog of Taxol

Minocycline Hydrochloride

Bulleyaconitine A

Crizotinib

ADU-S100 sodium salt

[DPhe7]-Bradykinin

Parasin I

Olmutinib

Loperamide Hydrochloride

Toremifene Base

Footer