Memantine Hydrochloride

Name: Memantine Hydrochloride
SKU: M1749
Availability: InStock

Product ID M1749

Cas No. 41100-52-1

Purity ≥97%

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Product Info
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References

Description

Memantine is an inhibitor of NMDA receptors that exhibits neuroprotective and cognition enhancing activities and is clinically used to treat Alzheimer’s disease, dementia, and Parkinson’s disease. Memantine also inhibits 5-HT3 receptors and α7 nicotinic acetylcholine receptors (nAChRs) and activates D2 receptors. Memantine improves spatial learning and memory impairments in various animal models and clinical settings. Additionally, memantine stimulates dendritic spine maturation and synapse formation in vivo.

Product Info

Cas No.	41100-52-1
Purity	≥97%
Formula	C₁₂H₂₁N • HCl
Formula Wt.	215.77
Chemical Name	3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
IUPAC Name	3,5-dimethyladamantan-1-amine;hydrochloride
Synonym	Akatinol
Melting Point	258°C
Solubility	Soluble in water.
Appearance	White or off-white crystals or crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M1749 MSDS PDF
Info Sheet	M1749 Info Sheet PDF
Brochure	Memantine Flyer

References

Liu MY, Wang S, Yao WF, et al. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience. 2014 Jul 25;273:141-51. PMID: 24846616.

Wei H, Dobkin C, Sheikh AM, et al. The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome. PLoS One. 2012;7(5):e36981. PMID: 22615862.

Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2009 Jul;8(7):613-8. PMID: 19520613.

Seeman P, Caruso C, Lasaga M. Memantine agonist action at dopamine D2High receptors. Synapse. 2008 Feb;62(2):149-53. PMID: 18000814.

Aracava Y, Pereira EF, Maelicke A, et al. Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. PMID: 15522999.

Rammes G, Rupprecht R, Ferrari U, et al. The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner. Neurosci Lett. 2001 Jun 22;306(1-2):81-4. PMID: 11403963.