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5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

Product ID I0010
Cas No. 1246535-95-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $99.60 In stock
25 mg $298.70 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

Desmethyl VS5584 Is an intermediate in the synthesis of purine analogs and potential tyrosine kinase inhibitor. This analog is a highly selective PI3K/mTOR kinase inhibitor.

Product Info

Cas No.

1246535-95-4

Purity

≥98%

Formula

C16H20N8O

Formula Wt.

340.39

IUPAC Name

5-[9-Isopropyl-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine

Synonym

Desmethyl-VS-5584, Desmethyl VS5584, Desmethyl VS 5584, VS-5584 Analog

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I0010 MSDS PDF

Info Sheet

I0010 Info Sheet PDF

References

Zhou C, Li X, He A, et al. Development of a UPLC-MS/MS method for the quantification of VS-5584 and its application in pharmacokinetic studies in rats. J Anal Methods Chem. 2020 Dec 16;2020:8811522. PMID: 33381351.

Chen Y, Tsai H, Tsai Y, et al. VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo. J Pediatr Surg. 2021 Aug;56(8):1441-1448. PMID: 33189297.

Xu M, Xu L, Wang Y, et al. BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584. Aging (Albany NY). 2020 Oct 13;12(19):19147-19158. PMID: 33051401.

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