LKT Labs

Biochemicals for Life Science Research

Evodiamine

Product ID E8657
Cas No. 518-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $88.20 In stock
250 mg $176.50 In stock
1 g $493.90 In stock
Bulk Quote

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Description

Evodiamine is an indole alkaloid originally found in Evodia rutaecarpa. This compound exhibits anticancer, anti-diabetic, antiviral, anti-angiogenic, and gastrointestinal motility modulating activities. In bladder cancer cells, evodiamine decreases levels of Mcl-1, inhibits signaling of mTOR, and enhances TRAIL-induced apoptosis. Evodiamine directly inhibits topoisomerases I and II (topoI, topoII), inducing G2/M phase cell cycle arrest in leukemia cells. In other in vitro models, evodiamine decreases VEGF release and tube formation. In diabetic/obese animal models, evodiamine decreases mTOR signaling and increases phosphorylation of AMPK, improving glucose tolerance. Additionally, this compound inhibits viral replication of Influenza A and suppresses gastric emptying and transit.

Product Info

Cas No.

518-17-2
Purity

≥98%
Formula

C19H17N3O
Formula Wt.

303.36
Melting Point

265-278°C
Appearance

Light Yellow Fine Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

E8657 MSDS PDF
Info Sheet

E8657 Info Sheet PDF

References

Zhang T, Qu S, Shi Q, et al. Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1. Int J Mol Sci. 2014 Feb 21;15(2):3154-71. PMID: 24566141.

Wang T, Kusudo T, Takeuchi T, et al. Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. PLoS One. 2013 Dec 31;8(12):e83264. PMID: 24391749.

Dai JP, Li WZ, Zhao XF, et al. A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus. PLoS One. 2012;7(8):e42706. PMID: 22900043.

Pan X, Hartley JM, Hartley JA, et al. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine. 2012 May 15;19(7):618-24. PMID: 22402246.

Shyu KG, Lin S, Lee CC, et al. Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity. Life Sci. 2006 Apr 4;78(19):2234-43. PMID: 16280136.

Wu CL, Hung CR, Chang FY, et al. Effects of evodiamine on gastrointestinal motility in male rats. Eur J Pharmacol. 2002 Dec 20;457(2-3):169-76. PMID: 12464363.

Sung B, Prasad S, Ravindran J, et al. Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic Biol Med. 2012 Nov 15;53(10):1977-1987. PMID: 22922338.

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