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PTC124

PTC124

Product ID P7608
Cas No. 775304-57-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $76.10 In stock
25 mg $270.00 In stock
100 mg $650.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PTC124 allows read-through of premature stop codons in mRNA, enabling proper protein translation. This compound is used to treat Duchenne muscular dystrophy (DMD) and cystic fibrosis as well as other nonsense mutation disorders.

Product Info

Cas No.

775304-57-9

Purity

≥98%

Formula

C15H9FN2O3

Formula Wt.

284.25

IUPAC Name

3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid

Synonym

PTC-124, Ataluren, Translarna™

Solubility

DMSO 57 mg/mL (200mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P7608 MSDS PDF

Info Sheet

P7608 Info Sheet PDF

References

Bushby K, Finkel R, Wong B, et al. Ataluren treatment of patients with nonsense mutation dystrophinopathy. Muscle Nerve. 2014 Oct;50(4):477-87. PMID: 25042182.

Ryan NJ. Ataluren: first global approval. Drugs. 2014 Sep;74(14):1709-14. PMID: 25193627.

Nagel-Wolfrum K, Möller F, Penner I, et al. Translational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations. Vis Neurosci. 2014 Sep;31(4-5):309-16. PMID: 24912600.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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