LKT Labs

Biochemicals for Life Science Research

Demeclocycline Hydrochloride

Product ID D1748
Cas No. 64-73-3
Purity ≥85%
Product Unit SizeCostQuantityStock
100 mg $62.70 In stock
250 mg $93.70 In stock
1 g $180.20 In stock
Bulk Quote

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Description

Demeclocycline is a tetracycline antibiotic found in Streptomyces. Like other tetracyclines, demeclocycline exhibits antibacterial efficacy by binding the 30S bacterial ribosomal subunit and inhibiting aminoacyl tRNA binding, therefore preventing protein translation and synthesis. Demeclocycline decreases expression of aquaporin 2 (AQP2) and adenylate cyclase 5/6, decreasing cAMP levels and preventing hyponatremia in SIADH. Demeclocycline also exhibits neuroprotective activity in cellular models of glutamate-induced neuronal death and in animal models of cerebral ischemia, potentially through the inhibition of calpain.

Product Info

Cas No.

64-73-3
Purity

≥85%
Formula

C21H21ClN2O8 • HCl
Formula Wt.

501.30
Chemical Name

[4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethyl- amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-1,11,-dioxo-2-naphthacenecarboxamide hydrochloride
IUPAC Name

(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-3,12-dioxo-4a,5,5a, 6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
Synonym

Clortetrin, Demetraciclina, Detravis, Mexocine
Solubility

Soluble in water (16 mg/mL), methanol (20 mg/mL).
Appearance

Yellow Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

D1748 MSDS PDF
Info Sheet

D1748 Info Sheet PDF

References

Kortenoeven ML, Sinke AP, Hadrup N, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. PMID: 24154696.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

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