LKT Labs

Biochemicals for Life Science Research

Ketotifen Fumarate

Product ID K1776
Cas No. 34580-14-8
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $54.50 In stock
1 g $75.00 In stock
Bulk Quote

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Description

Ketotifen is a second-generation antihistamine that exhibits anti-allergic, anti-asthma, anti-inflammatory, and immunosuppressive activities. Ketotifen inhibits H1 histamine receptors, phosphodiesterases (PDEs), and leukotriene receptors; it also acts as a mast cell stabilizer. In animal models of acute lung injury, ketotifen inhibits mast cell activation, suppresses activation of NF-κB, and downregulates expression of TNF-α, IL-1β, and IL-6. In animal models of Trichinella infection, this compound decreases humoral and cellular immune responses.

Product Info

Cas No.

34580-14-8
Purity

≥98%
Formula

C19H19NOS • C4H4O4
Formula Wt.

425.50
Chemical Name

4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H- benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
IUPAC Name

(E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3, 4-b]thiophen-4-one
Synonym

Allerkif, Totifen, Zaditen, Zasten
Melting Point

192°C(dec.)
Solubility

Soluble in water (10 mg/mL), ethanol (0.5 mg/mL), DMSO (25 mg/mL), DMF (25 mg/mL), methanol.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

K1776 MSDS PDF
Info Sheet

K1776 Info Sheet PDF

References

Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Doligalska M. Effect of ketotifen on the immune response in BALB/c mice infected with Trichinella spiralis. Wiad Parazytol. 2000;46(2):217-24. PMID: 16886340.

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