LKT Labs

Biochemicals for Life Science Research

GW-788388

GW-788388

Product ID G8800
Cas No. 452342-67-5
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $144.00 In stock
25 mg $447.00 In stock
Bulk Quote

Quicklinks

Description

GW-788388 inhibits activin receptor-like kinase 5 (ALK5), suppressing TGF-β activity; it exhibits anti-fibrotic and cardioprotective activities. GW-788388 increases survival in studies of Trypanosoma infection and prevents Chagas disease-induced development of cardiac fibrosis. This compound also attenuates systolic dysfunction and left ventricular remodeling in animal models of myocardial infarction. In animal models of diabetes, GW-788388 decreases the occurrence of renal fibrosis.

Product Info

Cas No.

452342-67-5
Purity

≥97%
Formula

C25H23N5O2
Formula Wt.

425.49
IUPAC Name

4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide
Synonym

GW788388, GW 788388
Solubility

DMSO Solubility: 15 mg/mL (35.25 mM)

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

G8800 MSDS PDF
Info Sheet

G8800 Info Sheet PDF

References

de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R2713

    Recombinant HCV-NS4 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • G1855

    Gentiopicroside

    Secoiridoid glycoside found in Gentiana and Cep...

    ≥95%
  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • B1653

    Benzyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥99%
  • S8147

    Sulindac Sulfide

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • P2992

    Phyllolitorin

    Peptide found in amphibian skin; GRP (BB1) and ...

    ≥95%
  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • C4274

    CKS-17

    Synthetic peptide, retroviral envelope protein ...

    ≥95%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • N8663

    NVP-LDE225 Diphosphate

    Smo inhibitor.

    ≥98%
  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥98%
  • A044176

    Abemaciclib

    CDK inhibitor.

    ≥98%
  • D5709

    Docetaxel

    Semi-synthetic analog of taxol; microtubule dep...

    ≥98%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • C6955

    Cromolyn Sodium

    Mast cell destabilizer; potential TRP antagonis...

    ≥99%
  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • H1673

    Hesperidin

    Flavonoid found in species of Citrus; COX-2 inh...

    ≥95%
  • I544766

    Intepirdine

    Selective 5-HT6 receptor antagonist

    ≥98%
  • R1878

    Retinyl Acetate

    Vitamin A derivative, acetate ester of retinol....

    ≥98%