Description
Demecolcine binds tubulin and induces microtubule depolymerization and prevents polymerization. Demecolcine forces ejection of the nucleus and is used in research models studying embryonic cloning.
Product Unit Size | Cost | Quantity | Stock |
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Demecolcine binds tubulin and induces microtubule depolymerization and prevents polymerization. Demecolcine forces ejection of the nucleus and is used in research models studying embryonic cloning.
Cas No. | 477-30-5 |
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Purity | ≥97% |
Formula | C21H25NO5 |
Formula Wt. | 371.43 |
Chemical Name | 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one |
IUPAC Name | 1,2,3,10-tetramethoxy-7-(methylamino)-6, 7-dihydro-5H-benzo[a]heptalen-9-one |
Synonym | N-methyl-N-desacetylcolchicine, Colcemid, Omaine |
Melting Point | 186°C |
Solubility | Soluble in alcohol, ether, chloroform, benzene or acidified water. |
Appearance | Pale Yellow Powder |
Store Temp | 4°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet |
Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.
Lan GC, Wu YG, Han D, et al. Demecolcine-assisted enucleation of goat oocytes: protocol optimization, mechanism investigation, and application to improve the developmental potential of cloned embryos. Cloning Stem Cells. 2008 Jun;10(2):189-202. PMID: 18373477.
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