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Duloxetine Hydrochloride

Duloxetine Hydrochloride

Product ID D8145
Cas No. 136434-34-9
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $92.00 In stock
250 mg $173.70 In stock
1 g $408.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Duloxetine hydrochloride is a competitive inhibitor of serotonin and norepinephrine transporters (SERT, NET) that is clinically used to treat depression, anxiety, neuropathy, fibromyalgia, and stress urinary incontinence. Duloxetine’s inhibition of neurotransmitter reuptake alters downstream signaling mediated by NMDA receptors and NO as well. The inhibitory activity of this compound on neurotransmitter reuptake is related to its antidepressant and anxiolytic characteristics. The effects of duloxetine as a treatment for neuropathy and fibromyalgia, however, are likely due to its antagonist activity at voltage-gated Nav1.7 Na+ channels, which are involved in fibromyalgia and pain signaling.

Product Info

Cas No.

136434-34-9

Purity

≥99%

Formula

C18H19NOS • HCl

Formula Wt.

333.88

Chemical Name

(+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride

IUPAC Name

(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; hydrochloride

Synonym

LY-248686 hydrochloride, Cymbalta, Ariclaim

Solubility

Soluble in water (5 mg/ml), methanol, DMSO (67 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D8145 MSDS PDF

Info Sheet

D8145 Info Sheet PDF

References

Wang SY, Calderon J, Kuo Wang G. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65. PMID: 20693878.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. PMID: 19480470.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

Müller N, Schennach R, Riedel M, et al. Duloxetine in the treatment of major psychiatric and neuropathic disorders. Expert Rev Neurother. 2008 Apr;8(4):527-36. PMID: 18416656.

Sweeney DD, Chancellor MB. Treatment of stress urinary incontinence with duloxetine hydrochloride. Rev Urol. 2005 Spring;7(2):81-6. PMID: 16985814.

Custom Order

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