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ARV-825

ARV-825

Product ID A706840
Cas No. 1818885-28-7
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $99.80 In stock
5 mg $262.50 In stock
25 mg $761.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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Description

ARV-825 is a small-molecule degrader of BET proteins that has been shown to inhibit acute myeloid leukemia cell proliferation and induce apoptosis. It has also been demonstrated that ARV-825 may inhibit cell proliferation, induce apoptosis, and induce cell cycle arrest in vitro against a multiple myeloma cell line, and inhibit cell growth in vivo in a mouse xenograft.

Product Info

Cas No.

1818885-28-7

Purity

≥99%

Formula

C46H47ClN8O9S

Formula Wt.

923.44

Chemical Name

2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-ylamino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide

IUPAC Name

2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide

Synonym

ARV825; SCHEMBL17162093; RWLOGRLTDKDANT-TYIYNAFKSA-N; BCP19950; CS-4776

Solubility

DMSO (1 mg/mL), DMF (5 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A706840 MSDS PDF

Info Sheet

A706840 Info Sheet PDF

References

Piya S, Mu H, Bhattacharya S, et al. BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. J Clin Invest. 2019 Feb 21;130. pii:120654. PMID: 30829648.

Lim SL, Damnernsawad A, Shyamsunder P, et al. Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations. Haematologica. 2019 Jan 3. pii:haematol.2018.201483. PMID: 30606790.

Saenz DT, Fiskus W, Qian Y, et al. Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells. Leukemia. 2017 Sep;31(9):1951-1961. PMID: 28042144.

Custom Order

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