Name: RAD51 inhibitor, B02
SKU: B560000
Availability: InStock

Description

B02 is a RAD51 inhibitor. RAD51 is a homologous recombination protein, involved in the repair of double strand breaks in DNA. It is often overexpressed in cancers, making it an interesting target for anti-cancer therapies. Suppressing RAD51 activity increases the sensitivity of cancer cells to other therapies. In human breast cancer cells, B02 increased the anti-cancer effect of doxorubicin, etoposide, topotecan, and cisplatin.

Product Info

Cas No.	1290541-46-6
Purity	≥98%
Formula	C₂₂H₁₇N₃O
Formula Wt.	339.40
IUPAC Name	3-Benzyl-2-[(E)-2-(3-pyridinyl)vinyl]-4(3H)-quinazolinone
Synonym	B02 RAD51 inhibitor;

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	B560000 MSDS PDF
Info Sheet	B560000 Info Sheet PDF

References

Huang F., Mazin A., et al. A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts. PLoS One. 9(6): e100993 (2014). PMID: 24971740.

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RAD51 inhibitor, B02

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