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RAD51 inhibitor, B02

Product ID B560000
Cas No. 1290541-46-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $157.50 In stock
100 mg $483.00 In stock
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  • Product Info
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  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

B02 is a RAD51 inhibitor. RAD51 is a homologous recombination protein, involved in the repair of double strand breaks in DNA. It is often overexpressed in cancers, making it an interesting target for anti-cancer therapies. Suppressing RAD51 activity increases the sensitivity of cancer cells to other therapies. In human breast cancer cells, B02 increased the anti-cancer effect of doxorubicin, etoposide, topotecan, and cisplatin.

Product Info

Cas No.

1290541-46-6

Purity

≥98%

Formula

C22H17N3O

Formula Wt.

339.40

IUPAC Name

3-Benzyl-2-[(E)-2-(3-pyridinyl)vinyl]-4(3H)-quinazolinone

Synonym

B02 RAD51 inhibitor;

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

B560000 MSDS PDF

Info Sheet

B560000 Info Sheet PDF

References

Huang F., Mazin A., et al. A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts. PLoS One. 9(6): e100993 (2014). PMID: 24971740.

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