• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Isoimperatorin

Isoimperatorin

Product ID I4962
Cas No. 482-45-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $101.00 In stock
25 mg $404.30 In stock
100 mg $1,123.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation in melanoma cells; separately, it prevents activation of carcinogens such as PBTA-4 and MelQ. In vivo, isoimperatorin decreases tumor growth and tumor weight when combined with UVA irradiation. In cellular models, this compound decreases expression of ROS and vascular cellular adhesion molecule 1 (VCAM-1), increases expression of PPAR-γ, and inhibits NF-κB-induced phosphorylation of Akt, ERK, and PKC. In other cell lines, isoimperatorin inhibits activity of cyclooxygenase (COX-2), preventing production of leukotriene C4 and degranulation of bone marrow-derived mast cells. Additionally, isoimperatorin exhibits activity against both gram positive and gram negative bacteria.

Product Info

Cas No.

482-45-1

Purity

≥98%

Formula

C16H14O4

Formula Wt.

270.28

Chemical Name

4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

IUPAC Name

4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

Appearance

Off-white crystals

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I4962 MSDS PDF

Info Sheet

I4962 Info Sheet PDF

References

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339

Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.

Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T7158

    Tropicamide

    mAChR antaonist.

    ≥98%
  • P4008

    PKC412

    Staurosporine derivative; PKC and FLT3 inhibito...

    ≥98%
  • C1878

    Cetrimide

    Mixture of quaternary ammonium salts, cationic ...

    ≥98%
  • A985130

    AZD-7762

    CHK1 inhibitor.

    ≥98%
  • T1024

    Baccatin VI

    Fermentation impurity

    ≥98%
  • A6229

    Aphidicolin

    Diterpene antibiotic produced by Cephalosporum;...

    ≥98%
  • D170310

    10,11-Dehydrocurvularin

    Fungal metabolite produced by Penicillium speci...

    ≥98%
  • A6268

    Aprotinin

    Polypeptide; serine protease inhibitor.

    ≥ 5400 u/mg
  • S520011

    SN-011

    STING antagonist

    ≥97%
  • P6857

    Protocatechuic Acid

    Polyphenol found in many plants and foods.

    ≥97%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • S6129

    D-Sphingosine

    Endogenous component of sphingolipids; PKC inhi...

    ≥98%
  • G1210

    GDC-0623

    MEK inhibitor.

    ≥98%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • T7035

    Triptolide

    Diterpenoid epoxide found in Tripterygium.

    ≥98%
  • T6830

    Triadimefon

    Neurotoxin, mutagen.

    ≥98%
  • D3374

    Disulfiram

    Aldehyde dehydrogenase, 26S proteasome, MGMT in...

    ≥98%
  • S3453

    Sinigrin Monohydrate, synthetic

    ITC precursor found in cruciferous vegetables.<...

    ≥98%
  • C294458

    Chlorzoxazone

    Centrally acting muscle relaxant.

    ≥99%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only