• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tandutinib

Tandutinib

Product ID T0152
Cas No. 387867-13-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $105.00 In stock
5 mg $315.00 In stock
25 mg $1,044.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tandutinib is an inhibitor of several kinases, including FMS-like tyrosine kinase 3 (FLT3), PDGFR, and Kit. Tandutinib exhibits anticancer chemotherapeutic and anti-angiogenic activities and currently shows mixed results in clinical trials as a potential treatment for several cancers. In vivo, tandutinib inhibits phosphorylation of c-Kit, Akt, mTOR, and p70S6 kinase; it also increases activation of caspase 3 and the ratio of Bax/Bcl-2 and decreases expression of cyclin D1, resulting in apoptosis. In animal models, tandutinib decreases expression of COX-2 and VEGF, decreasing vessel formation and inhibiting growth of colon cancer xenografts. In an in vivo model of medulloblastoma, this compound decreases tumor volume.

Product Info

Cas No.

387867-13-2

Purity

≥98%

Formula

C31H42N6O4

Formula Wt.

562.7

Chemical Name

4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

IUPAC Name

4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2- yloxyphenyl)piperazine-1-carboxamide

Synonym

CT53518; MLN518

Melting Point

177-178°C

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0152 MSDS PDF

Info Sheet

T0152 Info Sheet PDF

References

Ponnurangam S, Standing D, Rangarajan P, et al. Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. Mol Cancer Ther. 2013 May;12(5):598-609. PMID: 23427297.

Ohshima-Hosoyama S, Davare MA, Prajapati SI, et al. Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model. J Pediatr Hematol Oncol. 2012 Mar;34(2):116-21. PMID: 22146535.

Griswold IJ, Shen LJ, La Rosée P, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004 Nov 1;104(9):2912-8. PMID: 15242881.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1673

    Terlipressin Acetate

    Synthetic peptide, vasopressin analog; AVPR1 ag...

    ≥95%
  • F5773

    Fosinopril Sodium

    ACE inhibitor.

    ≥98%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • S5868

    Sorafenib

    c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...

    ≥98%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • E7228

    Ethacridine Lactate Monohydrate

    Aromatic acridine derivative, DNA intercalator....

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • P2845

    Phleomycin

    Glycopeptide, metal ion chelator, induces DNA s...

    ≥97%
  • S6019

    Speract

    Peptide, derived from egg outer envelope; K+ ch...

    ≥95%
  • S520011

    SN-011

    STING antagonist

    ≥97%
  • H9614

    Hydrochlorothiazide

    Thiazide diuretic; NCCT inhibitor, carbonic anh...

    ≥98%
  • P2400

    Phenethyl Caffeate

    Found in propolis; 5-lipoxygenase inhibitor.

    ≥98%
  • C451338

    Clioquinol

    Antifungal agent with neuroprotective activity....

    ≥98%
  • R3012

    Recombinant TpN 17 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • C1627

    Cefaclor Monohydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • P0254

    Panaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • S0253

    Sanguinarine

    Benzophenanthridine alkaloid found in various p...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only