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Tandutinib

Product ID T0152
Cas No. 387867-13-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $109.40 In stock
5 mg $520.30 In stock
25 mg $1,259.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

Tandutinib is an inhibitor of several kinases, including FMS-like tyrosine kinase 3 (FLT3), PDGFR, and Kit. Tandutinib exhibits anticancer chemotherapeutic and anti-angiogenic activities and currently shows mixed results in clinical trials as a potential treatment for several cancers. In vivo, tandutinib inhibits phosphorylation of c-Kit, Akt, mTOR, and p70S6 kinase; it also increases activation of caspase 3 and the ratio of Bax/Bcl-2 and decreases expression of cyclin D1, resulting in apoptosis. In animal models, tandutinib decreases expression of COX-2 and VEGF, decreasing vessel formation and inhibiting growth of colon cancer xenografts. In an in vivo model of medulloblastoma, this compound decreases tumor volume.

Product Info

Cas No.

387867-13-2

Purity

≥98%

Formula

C31H42N6O4

Formula Wt.

562.7

Chemical Name

4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

IUPAC Name

4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2- yloxyphenyl)piperazine-1-carboxamide

Synonym

CT53518; MLN518

Melting Point

177-178°C

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0152 MSDS PDF

Info Sheet

T0152 Info Sheet PDF

References

Ponnurangam S, Standing D, Rangarajan P, et al. Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. Mol Cancer Ther. 2013 May;12(5):598-609. PMID: 23427297.

Ohshima-Hosoyama S, Davare MA, Prajapati SI, et al. Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model. J Pediatr Hematol Oncol. 2012 Mar;34(2):116-21. PMID: 22146535.

Griswold IJ, Shen LJ, La Rosée P, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004 Nov 1;104(9):2912-8. PMID: 15242881.

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