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Clioquinol

Clioquinol

Product ID C451338
Cas No. 130-26-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $61.40 In stock
5 g $149.80 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Clioquinol is an antifungal agent that has exhibited neuroprotective and anticancer properties. It is a metal ionophore that inhibits growth of pathogenic fungi including strains of Candida and Aspergillus.

Treatment using clioquinol in models of Huntington’s disease in mice resulted in improved behavioral and pathologic phenotypes and extension of life span. The structural and functional features of clioquinol as a metal chelating aggregation modulator have been adapted in combination with epigallocatechin gallate to create a hybrid modulator that prevents the generation of reactive oxygen species and interrupting the interaction of toxic amyloid-beta species with mitochondria, making it a potential treatment for Alzheimer’s disease.

Product Info

Cas No.

130-26-7

Purity

≥98%

Formula

C9H55ClINO

Formula Wt.

305.50

IUPAC Name

5-chloro-7-iodoquinolin-8-ol

Synonym

5-Chloro-7-iodoquinolin-8-ol, Iodochlorhydroxyquin, Chinoform Chloroiodoquin, 5-Chloro-8-hydroxy-7-iodoquinoline

Solubility

Practically insoluble in water and in ethanol.

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C451338 MSDS PDF

Info Sheet

C451338 Info Sheet PDF

References

You Z., Ran X., et al. Clioquinol, an alternative antimicrobial agent against common pathogenic microbe. J Mycol Med. 28(3):492-501 (2018). PMID: 29650464.

Nguyen T., Hamby A., et al. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci. 102(33):11840-11845 (2005). PMID: 16087879.

Rajasekhar K., Mehta K., et al. Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage. ACS Chem Neurosci. 9(6):1432-1440 (2018). PMID: 29557650.

Custom Order

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