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Verubecestat

Product ID V182705
Cas No. 1286770-55-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $108.00 In stock
25 mg $328.50 In stock
100 mg $826.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

Verubecestat is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor. Verubecestat was found to reduce amyloid in plasma, cerebral spinal fluid, and brains in several animal models. However, development of verubecestat as a treatment was halted when it was shown to have no impact on slowing the progression of Alzheimer’s disease.

Product Info

Cas No.

1286770-55-5

Purity

≥98%

Formula

C17H17F2N5O3S

Formula Wt.

409.41

Chemical Name

N-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide

IUPAC Name

N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

Synonym

MK-8931, MK8931

Solubility

DMSO:81 mg/mL (197.84 mM); Ethanol:41 mg/mL (100.14 mM); Water:Insoluble

Shipping and Storage

Store Temp

-20°C

Downloads

MSDS

V182705 MSDS PDF

Info Sheet

V182705 Info Sheet PDF

References

Villarreal S, Zhao F, Hyde LA, et al. Chronic verubecestat treatment suppresses amyloid accumulation in advanced aged Tg2576-AbPPswe mice without inducing microhemorrhage. J Alzheimers Dis. 2017;59(4):1393-1413. PMID: 28800329.

Kennedy ME, Stamford AW, Chen X, et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS beta-amyloid in animal models and in Alzheimer’s disease patients. Sci Transl Med. 2016 Nov 2;8(363):363ra150. PMID: 27807285.

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