• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Verubecestat

Product ID V182705
Cas No. 1286770-55-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $127.10 In stock
25 mg $386.70 In stock
100 mg $973.50 In stock
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Verubecestat is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor. Verubecestat was found to reduce amyloid in plasma, cerebral spinal fluid, and brains in several animal models. However, development of verubecestat as a treatment was halted when it was shown to have no impact on slowing the progression of Alzheimer’s disease.

Product Info

Cas No.

1286770-55-5

Purity

≥98%

Formula

C17H17F2N5O3S

Formula Wt.

409.41

Chemical Name

N-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide

IUPAC Name

N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

Synonym

MK-8931, MK8931

Solubility

DMSO:81 mg/mL (197.84 mM); Ethanol:41 mg/mL (100.14 mM); Water:Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V182705 MSDS PDF

Info Sheet

V182705 Info Sheet PDF

References

Villarreal S, Zhao F, Hyde LA, et al. Chronic verubecestat treatment suppresses amyloid accumulation in advanced aged Tg2576-AbPPswe mice without inducing microhemorrhage. J Alzheimers Dis. 2017;59(4):1393-1413. PMID: 28800329.

Kennedy ME, Stamford AW, Chen X, et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS beta-amyloid in animal models and in Alzheimer’s disease patients. Sci Transl Med. 2016 Nov 2;8(363):363ra150. PMID: 27807285.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only