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Anastrozole

Anastrozole

Product ID A5302
Cas No. 120511-73-1
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $90.80 In stock
100 mg $191.50 In stock
250 mg $352.30 In stock
1 g $1,070.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Anastrozole is a third generation aromatase inhibitor that suppresses synthesis of estrogen. Anastrozole exhibits anticancer chemotherapeutic activity and is clinically used to treat ER-positive breast cancer. In vitro, anastrozole inhibits proliferation of cancer cells by disrupting the mitochondrial membrane potential and inducing apoptosis. Because of its anti-estrogen properties, anastrozole may decrease bone mineral density and increase fracture risk.

Product Info

Cas No.

120511-73-1

Purity

≥99%

Formula

C17H19N5

Formula Wt.

293.37

Chemical Name

2,2'-(5-(IH-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropiononitrile)

IUPAC Name

2-[3-(2-cyanopropan-2-yl)-5-(1,2, 4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

Synonym

ZD1033 Pure, Zeneca ZD1033

Melting Point

81-84°C

Solubility

soluble in methanol, acetone, ethanol (59 mg/mL), THF, ethyl acetate, chloroform, DMSO (40 mg/mL). Slightly soluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5302 MSDS PDF

Info Sheet

A5302 Info Sheet PDF

References

Kelly CM, Buzdar AU. Anastrozole. Expert Opin Drug Saf. 2010 Nov;9(6):995-1003. PMID: 20923259.

Hong Y, Chen S. Aromatase inhibitors: structural features and biochemical characterization. Ann N Y Acad Sci. 2006 Nov;1089:237-51. PMID: 17261771.

McCloskey E. Effects of third-generation aromatase inhibitors on bone. Eur J Cancer. 2006 May;42(8):1044-51. PMID: 16554149.

Xanthopoulos JM, Romano AE, Majumdar SK. Response of Mouse Breast Cancer Cells to Anastrozole, Tamoxifen, and the Combination. J Biomed Biotechnol. 2005;2005(1):10-19. PMID: 15689634.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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