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Pancuronium is a reversible, competitive inhibitor of post-synaptic nicotinic acetylcholine receptors (nAChRs) that acts as a non-depolarizing neuromuscular junction (NMJ) blocker. When used clinically, pancuronium induces skeletal muscle relaxation and acts as an anesthetic.
| Cas No. | 15500-66-0 |
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| Purity | ≥98% |
| Formula | C35H60Br2N2O4 |
| Formula Wt. | 732.67 |
| Chemical Name | 1,1'-(3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide |
| IUPAC Name | [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2, 16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide |
| Synonym | 5alpha-Androstan-3alpha, 17beta-diol, 2beta16beta-dipipecolinio-, dibromide, diacetate |
| Melting Point | 214-217C |
| Solubility | 0.1 g/ml H2O clear, colorless |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Johnson PN, Miller J, Gormley AK. Continuous-infusion neuromuscular blocking agents in critically ill neonates and children. Pharmacotherapy. 2011 Jun;31(6):609-20. PMID: 21923445.
Jonsson M, Gurley D, Dabrowski M, et al. Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology. 2006 Sep;105(3):521-33. PMID: 16931985.
Motamed C, Kirov K, Lieutaud T, et al. The mechanism of pancuronium potentiation of mivacurium block: use of the isolated-arm technique. Anesth Analg. 2000 Sep;91(3):732-5. PMID: 10960409.
