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BMS-708163

Product ID B5075
Cas No. 1146699-66-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.30 In stock
5 mg $244.90 In stock
25 mg $750.10 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BMS-708163 is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective activity. BMS-708163 decreases the formation of amyloid-β (Aβ) plaques and is in clinical trials as a potential treatment for Alzheimer’s disease.

Product Info

Cas No.

1146699-66-2

Purity

≥98%

Formula

C20H17ClF4N4O4S

Formula Wt.

520.88

IUPAC Name

N2-[(4-Chlorophenyl)sulfonyl]-5,5,5-trifluoro-N2-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]norvalinamide

Synonym

Avagacestat, BMS708163

Solubility

DMSO Solubility: 104 mg/mL (199.66 mM)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B5075 MSDS PDF

Info Sheet

B5075 Info Sheet PDF

References

Tong G, Castaneda L, Wang JS, et al. Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men. Clin Drug Investig. 2012 Nov;32(11):761-9. PMID: 23018285.

Gillman KW, Starrett JE Jr, Parker MF, et al. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. ACS Med Chem Lett. 2010 Mar 22;1(3):120-4. PMID: 24900185.

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