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YM-155

Product ID Y4800
Cas No. 781661-94-7
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $68.10 In stock
5 mg $134.00 In stock
10 mg $214.90 In stock
25 mg $395.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

YM-155 is an inhibitor of survivin, an inhibitor of apoptosis protein (IAP) that displays anticancer chemotherapeutic activity. YM-155 is currently undergoing clinical trials and shows efficacy in the treatment of prostate cancer. YM-155 induces apoptosis in cellular models of neuroblastoma and inhibits tumor growth in vivo. Additionally, this compound downregulates expression of Mcl-1 and increases activation of caspases 3 and 8, suppressing cell growth in leukemia cells.

Product Info

Cas No.

781661-94-7

Purity

≥99%

Formula

C20H19N4O3Br

Formula Wt.

443.29

Chemical Name

Sepantronium bromide

IUPAC Name

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide

Synonym

YM155, Sepantronium bromide

Solubility

Water 89 mg/mL (200.77 mM) DMSO 55 mg/mL (124.07 mM) Ethanol 6 mg/mL (13.53 mM)

Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Y4800 MSDS PDF

Info Sheet

Y4800 Info Sheet PDF

References

Liang H, Zhang L, Xu R, et al. Silencing of survivin using YM155 induces apoptosis and chemosensitization in neuroblastomas cells. Eur Rev Med Pharmacol Sci. 2013 Nov;17(21):2909-15. PMID: 24254560.

Feng W, Yoshida A, Ueda T. YM155 induces caspase-8 dependent apoptosis through downregulation of survivin and Mcl-1 in human leukemia cells. Biochem Biophys Res Commun. 2013 May 24;435(1):52-7. PMID: 23618862.

Tolcher AW, Quinn DI, Ferrari A, et al. A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer. Ann Oncol. 2012 Apr;23(4):968-73. PMID: 21859898.

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