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Estriol

Estriol

Product ID E7377
Cas No. 50-27-1
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $41.10 In stock
500 mg $94.80 In stock
1 g $164.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Estriol is an endogenous estrogenic steroid hormone with mixed agonist/antagonist activity. Estriol exhibits some anti-inflammatory and antithrombotic activities. Estriol decreases inflammatory cytokine production and improves neuronal pathology and symptoms of multiple sclerosis in clinical settings and in experimental autoimmune encephalitis (EAE) animal models. Estriol induces release of NO through the activation of NOS, causing lysis of platelet-rich plasma and inhibiting platelet aggregation. Additionally, estriol may be used to visualize the prolapsed vitreous body in the anterior chamber of the eye after posterior capsule rupture.

Product Info

Cas No.

50-27-1

Purity

≥97%

Formula

C18H24O3

Formula Wt.

288.38

Chemical Name

(16α,17β)-Estra-1,3,5(10)-triene-3,16,17-triol

IUPAC Name

(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16, 17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

Synonym

Aacifemine, Colpogyn, Destriol, Oekolp, Ovesterin, Theelol, Tridestrin

Melting Point

282°C

Solubility

Soluble in alcohol, dioxane, chloroform, ether, vegetable oils, pyridine or fixed alkali hydroxide solutions.

Appearance

White or almost white crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7377 MSDS PDF

Info Sheet

E7377 Info Sheet PDF

References

Jana P, Maiti S, Kahn NN, et al. Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets. Blood Coagul Fibrinolysis. 2014 Apr 2. [Epub ahead of print]. PMID: 24695088.

Tiwari-Woodruff S, Voskuhl RR. Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice. J Neurol Sci. 2009 Nov 15;286(1-2):81-5. PMID: 19442988.

Huang R, Kaji Y, Fukuda S, et al. Experimental use of estriol for visualizing the vitreous body in the anterior chamber after posterior capsule rupture in animal models. J Cataract Refract Surg. 2009 Jul;35(7):1260-5. PMID: 19545818.

Melamed M, Castaño E, Notides AC, et al. Molecular and kinetic basis for the mixed agonist/antagonist activity of estriol. Mol Endocrinol. 1997 Nov;11(12):1868-78. PMID: 9369454.

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