LKT Labs

Biochemicals for Life Science Research

Octreotide Acetate

Product ID O1078
Cas No. 79517-01-4
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $100.90 In stock
5 mg $302.10 In stock
25 mg $755.90 In stock
Bulk Quote

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Description

Octreotide is a somatostatin peptide analog that acts at somatostatin receptors and inhibits the release of growth hormone. Octreotide exhibits anticancer, anti-fibrotic, anti-inflammatory, and immunomodulatory activities. Octreotide inhibits colon cancer cell growth through the suppression of Wnt/β-catenin signaling. Octreotide inhibits hepatic stellate cell proliferation, downregulating the expression of TGF-β, α-SMA, Smad-4a, c-Jun, sp-1, ET-1, and collagen; it is also protective against fibrosis in animal models. Additionally, octreotide inhibits peripheral blood mononuclear cell proliferation, decreasing levels of IL-6, IL-10, and IFN-γ and producing clinical improvements in subjects with systematic lupus erythematous.

Product Info

Cas No.

79517-01-4
Purity

≥95%
Formula

C49H66N10O10S2 • 2C2H4O2
Formula Wt.

1139.36
Chemical Name

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D- tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1- (hydroxymethyl)propyl]-L-cysteinamide cyclic (2->7)-disulfide acetate (salt)
IUPAC Name

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1, 3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9, 12,15,18-pentaoxo-1,2-dithia-5,8,11,14, 17-pentazacycloicosane-4-carboxamide
Synonym

Sandostatin

Solubility

Soluble in methanol. Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O1078 MSDS PDF
Info Sheet

O1078 Info Sheet PDF
Brochures

WNT Booklet

References

Wang S, Bao Z, Liang QM, et al. Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3β, A Wnt/β-catenin pathway modulator. Hepatogastroenterology. 2013 Oct;60(127):1639-46. PMID: 24634935.

Wang J, Wang L, Song G, et al. The mechanism through which octreotide inhibits hepatic stellate cell activity. Mol Med Rep. 2013 May;7(5):1559-64. PMID: 23525276.

Tug T, Kara H, Karaoglu A, et al. The effect of octreotide, an analog of somatostatin, on bleomycin-induced interstitial pulmonary fibrosis in rats. Drug Chem Toxicol. 2013 Apr;36(2):181-6. PMID: 22946449.

Zhang Y, Huang W, Li F, et al. Octreotide for the treatment of systemic lupus erythematosus: clinical effects and an in vitro study on its therapeutic mechanism. Lupus. 2011 Oct;20(11):1172-81. PMID: 21979989.

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