LKT Labs

Biochemicals for Life Science Research

A 83-01

A 83-01

Product ID A001001
Cas No. 909910-43-6
Purity ≥98%
Unit SizeCostQuantityStock
5 mg $60.00 In stock
25 mg $235.00 In stock
100 mg $680.00 In stock
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Description

A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.

Product Info

Cas No.

909910-43-6

Purity

≥98%

Formula

C25H19N5S

Formula Wt.

421.52

Chemical Name

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

IUPAC Name

3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide

Synonym

A83-01; ALK5 Inhibitor IV; 1H-Pyrazole-1-carbothioamide,3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-

Solubility

Soluble in DMSO 1mg/mL in ethanol 2.5mg/mL in ethyl acetate

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Downloads

MSDS

A001001 MSDS PDF

Info Sheet

A001001 Info Sheet PDF

References

Katsuda T, Kawamata M, Hagiwara K, et al. Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. PMID: 27840021.

Wang H, Liu S, Wang Y, et al. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016 Jan 14;16(2):126-131. PMID: 26773180.

Nishino Y, Murakami M, Funaba M. Expression and role of the TGF-beta family in glial cells infected with Borna disease virus. Microbes Infect. 2016 Feb;18(2):128-136. PMID: 26482505.

Ho YS, Tsai WH, Lin FC, et al. Cardioprotective actions of TGFbetaRI inhibition through stimulating autocrine/paracrine of survivin and inhibiting Wnt in cardiac progenitors. Stem Cells. 2016 Feb;34(2):445-455. PMID: 26418219.

Sun X, Kim YH, Phan TN, et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem. 2014;78(11):1805-1812. PMID: 25351330.

Nishino Y

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