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Dehydrocorydaline

Product ID D1631
Cas No. 30045-16-0
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $115.80 In stock
5 mg $454.70 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Dehydrocorydaline is an alkaloid compound originally found in Corydalis tubers that exhibits anticancer, anti-inflammatory, and anti-allergic activities. In breast cancer cells, dehydrocorydaline increases activation of caspases 7 and 8, cleavage of poly(ADP)-ribose polymerase (PARP), and the Bax/Bcl-2 ratio, inducing DNA fragmentation and inhibiting proliferation. In macrophages, this compound inhibits LPS-induced increases in IL-6 and IL-1β as well as alterations in the mitochondrial membrane potential. Dehydrocorydaline inhibits passive cutaneous anaphylaxis (type I hypersensitivity), contact dermatitis (type IV hypersensitivity), and mast cell degranulation in animal models of allergies. Additionally, dehydrocorydaline also inhibits acetylcholinesterase (AChE).

Product Info

Cas No.

30045-16-0

Purity

≥95%

Formula

C22H24NO4

Formula Wt.

366.43

IUPAC Name

2,3,9,10-tetramethoxy-13-methyl-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium

Solubility

10 mM in DMSO

Appearance

Yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D1631 MSDS PDF

Info Sheet

D1631 Info Sheet PDF

References

Xu Z, Chen X, Fu S, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. Erratum in: Am J Chin Med. 2012;40(6):1323. PMID: 22298457.

Ishiguro K, Ando T, Maeda O, et al. Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages. Int Immunopharmacol. 2011 Sep;11(9):1362-7. PMID: 21575743.

Xiao HT, Peng J, Liang Y, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22. PMID: 20234973.

Matsuda H, Tokuoka K, Wu J, et al. Inhibitory effects of dehydrocorydaline isolated from Corydalis Tuber against type I-IV allergic models. Biol Pharm Bull. 1997 Apr;20(4):431-4. PMID: 9145224.

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