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Ginkgolide C is a diterpene lactone found in Ginkgo; it exhibits anticoagulant, neuromodulatory, and antioxidative activities. Ginkgolide C increases levels of matrix metalloproteinase 9 (MMP9), cAMP, and cGMP, suppresses production of thromboxane A2 (TxA2), and inhibits platelet aggregation in vitro. Ginkgolide C inhibits GABA-A receptors, α-1 glycine receptors, and PAF receptors. In cellular models, ginkgolide C inhibits formation of superoxide and hydroxyl radicals.
| Cas No. | 15291-76-6 |
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| Purity | ≥98% |
| Formula | C20H24O11 |
| Formula Wt. | 440.40 |
| Chemical Name | (1α,7β)-1,7-Dihydroxyginkolide A |
| IUPAC Name | (1R,3R,6R,7S,8S,9R,10S,11R,12S,13S,16S,17R)-8-tert-butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione |
| Synonym | BN-52022 |
| Melting Point | ~300°C(dec.) |
| Solubility | Insoluble in water. Soluble in DMSO. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cho HJ, Shon YH, Nam KS. Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9. Biol Pharm Bull. 2007 Dec;30(12):2340-4. PMID: 18057723.
Huang SH, Duke RK, Chebib M, et al. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol. 2004 Jun 28;494(2-3):131-8. PMID: 15212966.
Jaracz S, Nakanishi K, Jensen AA, et al. Ginkgolides and glycine receptors: a structure-activity relationship study. Chemistry. 2004 Mar 19;10(6):1507-18. PMID: 15034895.
Scholtyssek H, Damerau W, Wessel R, et al. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact. 1997 Oct 24;106(3):183-90. PMID: 9413545.