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Ifenprodil Hemitartrate

Ifenprodil Hemitartrate

Product ID I2118
Cas No. 23210-58-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $79.00 In stock
25 mg $118.30 In stock
50 mg $197.40 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
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Description

Ifenprodil is an antagonist at NMDA receptors specific for NR1 and NR2B subunits; it exhibits neuromodulatory, anticancer, anticonvulsant, cognition enhancing, and vasodilatory effects. In cellular and animal models of ovarian cancer, ifenprodil decreases cellular viability and tumor growth. Ifenprodil also inhibits PTZ-induced hippocampal oxidative stress, astrocytosis, and neuron loss. Additionally, this compound reverses motor deficits when co-administered with L-DOPA in Parkinson’s disease models and prevents rapamycin-induced memory impairment. In vivo, ifenprodil also induces mild vasodilation, decreasing blood pressure and increasing heart rate.

Product Info

Cas No.

23210-58-4

Purity

≥98%

Formula

C21H28NO2 • C4H4O6

Formula Wt.

474.53

IUPAC Name

4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol;(2R,3R)-2,3-dihydroxybutanedioic acid

Solubility

15mM in water with gentle warming

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I2118 MSDS PDF

Info Sheet

I2118 Info Sheet PDF

References

North WG, Liu F, Tian R, et al. NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines. Clin Pharmacol. 2015 Oct 23;7:111-7. PMID: 26566373.

Sirrieh RE, MacLean DM, Jayaraman V. A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc. J Gen Physiol. 2015 Aug;146(2):173-81. PMID: 26170175.

Igarashi M, Habata T, Akita H, et al. The NR2B antagonist, ifenprodil, corrects the l-DOPA-induced deficit of bilateral movement and reduces c-Fos expression in the subthalamic nucleus of hemiparkinsonian rats. Neurosci Res. 2015 Jul;96:45-53. PMID: 25697393.

Shatillo A, Salo RA, Giniatullin R, et al. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. Neuropharmacology. 2015 Jun;93:164-70. PMID: 25688928.

Zhu X, Dong J, Shen K, et al. NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015 May;114:70-8. PMID: 25896886.

Ozawa H, Chen CS, Uematsu T, et al. Analysis of the mode of action of ifenprodil on cerebral and peripheral circulation in dogs. Nihon Yakurigaku Zasshi. 1975 Jul;71(5):517-26. PMID: 1238323.

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