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Clobetasol Propionate

Product ID C4659
Cas No. 25122-46-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $45.00 In stock
500 mg $65.00 In stock
1 g $85.00 In stock
5 g $198.00 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Clobetasol is a corticosteroid that activates glucocorticoid receptors and exhibits anti-inflammatory and immunosuppressive activities. Clobetasol is clinically used to treat eczema, psoriasis, contact dermatitis, and several autoimmune diseases. Clobetasol inhibits TNF-α- and CD40L-induced activation of NF-κB in vitro.

Product Info

Cas No.

25122-46-7

Purity

≥98%

Formula

C25H32ClFO5

Formula Wt.

466.98

Chemical Name

(11β, 16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16- methylpregna-1,4-diene-3,20-dione

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S, 17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6, 7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Synonym

Clobesol, Dermoval, Dermovate, Dermoxin, Temovate

Melting Point

195.5-197°C

Solubility

Soluble in acetone or methylene dichloride.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C4659 MSDS PDF

Info Sheet

C4659 Info Sheet PDF

References

Cechin SR, Buchwald P. Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells. Steroids. 2014 Jul;85:36-43. PMID: 24747770.

Lenane P, Macarthur C, Parkin PC, et al. Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in children: a randomized clinical trial. JAMA Dermatol. 2014 Jan;150(1):47-50. PMID: 24226568.

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