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Tunicamycin

Product ID T8153
Cas No. 11089-65-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $55.40 In stock
5 mg $185.30 In stock
10 mg $351.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Tunicamycin is a nucleoside antibiotic mixture that inhibits glycoprotein synthesis. Tunicamycin prevents N-glycosylation by inhibiting GlcNAc phosphotransferase and other enzymes, inducing G1 phase cell cycle arrest in vitro. Tunicamycin displays anti-inflammatory activity, inhibiting toll-like receptor (TLR) activation-induced inflammation by decreasing activation of NF-κB, activity of CRE, and expression of iNOS, COX-2, TNF-α, and IL-1β in macrophages.

Product Info

Cas No.

11089-65-9

Purity

≥98%

Formula

C40H66N4O16

Formula Wt.

Avg. 840.0

IUPAC Name

(E)-N-[(2R,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[(2R,3S,4R,5R)-5-(2, 4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4, 5-dihydroxyoxan-3-yl]-5-methylhex-2-enamide

Melting Point

234-235°C

Solubility

Soluble in DMSO and DMF.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T8153 MSDS PDF

Info Sheet

T8153 Info Sheet PDF

References

Kim SY, Hwang JS, Han IO. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-κB and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300. PMID: 24056124.

Pertusa M, Madrid R, Morenilla-Palao C, et al. N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem. 2012 May 25;287(22):18218-29. PMID: 22493431.

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