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AZD-1208

Product ID A9708
Cas No. 1204144-28-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $162.00 In stock
5 mg $471.30 In stock
10 mg $868.10 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

AZD-1208 is a Pim-1 kinase inhibitor that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells, AZD-1208 induces cell cycle arrest and apoptosis, inhibiting phosphorylation of downstream targets such as Bcl-2, 4EBP1, p70S6K, and S6 and suppressing cell growth. In vivo, AZD-1208 inhibits growth of prostate tumor xenografts.

Product Info

Cas No.

1204144-28-4

Purity

≥98%

Formula

C21H21N3O2S

Formula Wt.

379.48

IUPAC Name

(5E)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione

Solubility

DMSO 75 mg/mL warmed (197.63 mM) Water Insoluble Ethanol Insoluble

Appearance

Pale Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A9708 MSDS PDF

Info Sheet

A9708 Info Sheet PDF

References

Kirschner AN, Wang J, van der Meer R, et al. PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer. J Natl Cancer Inst. 2014 Dec 13;107(2). PMID: 25505253.

Keeton EK, McEachern K, Dillman KS, et al. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014 Feb 6;123(6):905-13. PMID: 24363397.

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