Palbociclib Isethionate

Name: Palbociclib Isethionate
SKU: P0344
Availability: InStock

Product ID P0344

Cas No. 827022-33-3

Purity ≥98%

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Product Info
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Description

Palbociclib is an inhibitor of CDK4 and CDK6 that displays anticancer chemotherapeutic and nephroprotective activities; it is currently in clinical trials as a potential treatment for breast cancer. Palbociclib induces G0/G1 phase cell cycle arrest in renal proximal tubule cells, protecting animals against nephrotoxicity and inflammation induced by other chemotherapeutics. Palbociclib also induces cell cycle arrest in cellular and animal models of glioma, increasing overall survival times. In animal models of retinoblastoma, this compound inhibits cell proliferation, and induces G1 phase cell cycle arrest and tumor regression.

Product Info

Cas No.	827022-33-3
Purity	≥98%
Formula	C₂₄H₂₉N₇O₂ • C₂H₆O₄S
Formula Wt.	573.66
IUPAC Name	2-Hydroxyethanesulfonic acid - 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (1:1)
Synonym	PD0332991-0054, PF00080665-73
Solubility	Water 10 mg/mL warmed (17.43 mM) DMSO Insoluble Ethanol Insoluble
Appearance	Yellow to pale yellow powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P0344 MSDS PDF
Info Sheet	P0344 Info Sheet PDF

References

Vaughn DJ, Hwang W, Lal P, et al. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer. 2014 Dec 18. [Epub ahead of print]. PMID: 25522918.

DiRocco DP, Bisi J, Roberts P, et al. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F379-88. PMID: 24338822.

Barton KL, Misuraca K, Cordero F, et al. PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. PLoS One. 2013 Oct 2;8(10):e77639. PMID: 24098593.

Fry DW, Harvey PJ, Keller PR, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. PMID: 15542782.