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Veratridine

Product ID V1871
Cas No. 71-62-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $68.10 In stock
10 mg $128.80 In stock
25 mg $264.80 In stock
100 mg $787.00 Please Inquire
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Description

Veratridine is an alkaloid from the plant Liliaceae that has been shown to exhibit synergistic anti-tumor effects in combination with chemotherapeutic drugs. It has been found to upregulate the Ubiquitin-like-domain-containing protein UBXN2A in the cytoplasm, which then induces cell death. In other studies, Veratridine binds to neurotoxin receptor site 2 on voltage-gated sodium channels, which then inhibits inactivation of the channel. This binding site is also the target for various antiepileptic drugs. An increase in the non-inactivating sodium current has been associated with mutations on the voltage-gated sodium channel that cause epilepsy.

Product Info

Cas No.

71-62-5

Purity

≥98%

Formula

C36H51NO11

Formula Wt.

673.8

Chemical Name

[(1R,2S,6S,9S,10R,11S,12S,14R,15S,18S,19S,22S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] 3,4-dimethoxybenzoate

IUPAC Name

(3β,4α,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3-yl 3,4-dimethoxybenzoate

Synonym

3-Veratroylveracevine

Melting Point

180°C

Solubility

DMSO (25 mg/ml), ethanol (25 mg/ml)

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V1871 MSDS PDF

Info Sheet

V1871 Info Sheet PDF

References

Abdullah A, Sane S, Branick KA, et al. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15; 6(27): 23561-23581. PMID: 26188124.

Fekete A, Franklin L, Ikemoto T, Rózsa B, Lendvai B, Sylvester Vizi E, Zelles T. Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy. J Neurochem. 2009 Nov;111(3):745-56. doi: 10.1111/j.1471-4159.2009.06368.x. Epub 2009 Aug 31 PMID: 19719824.

Chen M1, Xiao CY, Hashizume H, Abiko Y. Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes. Eur J Pharmacol. 1997 Aug 27;333(2-3):261-8. PMID: 9314043.

Koike T, Tanaka S, Oda1 T, Ninomiya T. Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro. Brain Res Bull. 2000 Mar 1;51(4):345-55, PMID: 10704786

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