Ibudilast

Name: Ibudilast
SKU: I0480
Availability: InStock

Product ID I0480

Cas No. 50847-11-5

Purity ≥98%

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Description

Ibudilast is an inhibitor of phosphodiesterases 3 and 5 (PDE3/5) that also inhibits the leukotriene D4 (LTD4) receptor in airway smooth muscle cells. Ibudilast exhibits vasodilatory, anti-inflammatory, anti-asthma, anti-platelet, analgesic, and antinociceptive activities. In clinical settings, ibudilast increases cerebral blood flow in several brain regions after ischemic stroke. Ibudilast also non-competitively inhibits the functions of pro-inflammatory macrophage migration inhibitory factor (MIF), preventing glial cell activation. In other cellular models, ibudilast decreases activation of NF-κB, inhibiting HIV-1 Tat-induced production of TNF-α.

Product Info

Cas No.	50847-11-5
Purity	≥98%
Formula	C₁₄H₁₈N₂O
Formula Wt.	230.31
IUPAC Name	2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Synonym	3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine, KC-404, AV-411
Melting Point	53-54°C
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	I0480 MSDS PDF
Info Sheet	I0480 Info Sheet PDF

References

Inoue N, Fukuda S, Inada T, et al. Effect of ibudilast on the reciprocal inhibitory visual-vestibular interaction closely related to dizziness after cerebral ischemia. J Stroke Cerebrovasc Dis. 2014 Jan;23(1):51-5. PMID: 23085301.

Kiebala M, Maggirwar SB. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One. 2011 Apr 8;6(4):e18633. PMID: 21494611.

Cho Y, Crichlow GV, Vermeire JJ, et al. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11313-8. PMID: 20534506.

Ledeboer A, Hutchinson MR, Watkins LR, et al. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs. 2007 Jul;16(7):935-50. PMID: 17594181.

Kishi Y, Ohta S, Kasuya N, et al. Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanism. J Cardiovasc Pharmacol. 2000 Jul;36(1):65-70. PMID: 10892662.

Ohashi M, Kanai R, Nishino K, et al. Antagonistic effect of KC-404, a new anti-asthmatic agent, on leukotriene D4-induced contractile responses in isolated guinea pig smooth muscles. Prostaglandins. 1986 Dec;32(6):875-88. PMID: 3562868.

Ohashi M, Ohkubo H, Kito J, et al. A new vasodilator 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (KC-404) has a dual mechanism of action on platelet aggregation. Arch Int Pharmacodyn Ther. 1986 Oct;283(2):321-34. PMID: 3024600.

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Ibudilast

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