LKT Labs

Biochemicals for Life Science Research

Cladribine

Product ID C4402
Cas No. 4291-63-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $83.40 In stock
10 mg $138.90 In stock
25 mg $277.70 In stock
Bulk Quote

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Description

Cladribine is a deoxyadenosine analog that exhibits immunosuppressive and anticancer chemotherapeutic activities. Cladribine is used clinically to treat hairy cell leukemia and has shown mixed results as a potential treatment for multiple sclerosis. Cladribine induces apoptosis in monocyte-derived dendritic cells. Across many cellular models, this compound decreases levels of circulating B and T lymphocytes and inhibits growth of both proliferating and quiescent cells. As a nucleoside analog, cladribine inhibits DNA polymerase and ribonucleotide reductase, suppressing DNA repair and synthesis.

Product Info

Cas No.

4291-63-8
Purity

≥98%
Formula

C10H12ClN5O3

Formula Wt.

285.69
IUPAC Name

(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
Synonym

2-CdA, 2-Chlorodeoxyadenosine
Melting Point

210-220C
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4402 MSDS PDF
Info Sheet

C4402 Info Sheet PDF

References

Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013 Aug;173(2):288-97. PMID: 23607690.

Comi G, Hartung HP, Kurukulasuriya NC, et al. Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Pharmacother. 2013 Jan;14(1):123-36. PMID: 23256518.

Leist TP, Weissert R. Cladribine: mode of action and implications for treatment of multiple sclerosis. Clin Neuropharmacol. 2011 Jan-Feb;34(1):28-35. PMID: 21242742.

Robak T, Korycka A, Robak E. Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat Anticancer Drug Discov. 2006 Jan;1(1):23-38. PMID: 18221024.

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