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GSK-2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-α kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK-2606414 exhibits anticancer chemotherapeutic benefit, inhibiting growth of tumor xenografts in animal models.
| Cas No. | 1337531-89-1 |
|---|---|
| Purity | ≥99% |
| Formula | C24H20F3N5O |
| Formula Wt. | 451.44 |
| IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone |
| Solubility | DMSO 90 mg/mL (199.36 mM) Ethanol 19 mg/mL (42.08 mM) Water Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Axten JM, Medina JR, Feng Y, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. PMID: 22827572.
