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GSK-2606414

Product ID G7345
Cas No. 1337531-89-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
5 mg $189.80 In stock
25 mg $606.90 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GSK-2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-α kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK-2606414 exhibits anticancer chemotherapeutic benefit, inhibiting growth of tumor xenografts in animal models.

Product Info

Cas No.

1337531-89-1

Purity

≥99%

Formula

C24H20F3N5O

Formula Wt.

451.44

IUPAC Name

1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone

Solubility

DMSO 90 mg/mL (199.36 mM) Ethanol 19 mg/mL (42.08 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G7345 MSDS PDF

Info Sheet

G7345 Info Sheet PDF

References

Axten JM, Medina JR, Feng Y, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. PMID: 22827572.

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