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Doxorubicin Hydrochloride

Product ID D5794
Cas No. 25316-40-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $37.80 In stock
10 mg $54.00 In stock
50 mg $118.80 In stock
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  • Product Info
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  • References
  • Description
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Description

Doxorubicin is an anthracycline that exhibits anticancer chemotherapeutic and anti-parasitic, antimalarial activities. Doxorubicin is a DNA intercalator that inhibits topoisomerase II and is clinically used to treat various cancers; it is part of the CHOP and ABVD chemotherapy regimens. Doxorubicin also promotes histone H2AX eviction from chromatin, limiting DNA repair mechanisms. Additionally, this compound inhibits growth of Plasmodium.

Product Info

Cas No.

25316-40-9

Purity

≥98%

Formula

C27H29NO11 • HCl

Formula Wt.

579.99

Chemical Name

(8S-cis)10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo- hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroacetyl)-1-methoxy-5,12- naphthacenedione

IUPAC Name

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9, 11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5, 12-dione;hydrochloride

Synonym

Adriacin, Adriblastina, Adriamycin, Caelyx

Melting Point

204-205°C(dec.)

Solubility

Soluble in water, methanol or aqueous alcohols. Soluble in DMSO to 10 mg/mL. Insoluble in acetone or chloroform.

Appearance

Orange-Red Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D5794 MSDS PDF

Info Sheet

D5794 Info Sheet PDF

References

Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.

Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013 Feb;65(2):157-70. PMID: 23278683.

Gamo FJ, Sanz LM, Vidal J, et al. Thousands of chemical starting points for antimalarial lead identification. Nature. 2010 May 20;465(7296):305-10. PMID: 20485427.

Squillace RM, Miller D, Cookson M, et al. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol Cancer Ther. 2011 Oct;10(10):1959-1968. PMID: 21825008.

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