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Rivastigmine Tartrate

Rivastigmine Tartrate

Product ID R3586
Cas No. 129101-54-8
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $225.30 In stock
250 mg $451.00 In stock
1 g $1,352.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rivastigmine is an inhibitor of acetylcholinesterase (AChE) and butylcholinesterase (BChE) that is used clinically to treat dementia. Rivastigmine exhibits anti-cholinergic, anti-inflammatory, cognition enhancing and neuroprotective activities. In vivo, rivastigmine improves memory impairment in a CaMKII-dependent manner. Rivastigmine also decreases production of IL-1β in vivo. In vitro, this compound displays benefit against Alzheimer’s disease, increasing secretion of amyloid-β (Aβ) precursor protein (APP) and decreasing secretion of Aβ through modulation of α-secretase signaling.

Product Info

Cas No.

129101-54-8

Purity

≥99%

Formula

C14H22N2O2 • C4H6O6

Formula Wt.

400.43

Chemical Name

(2R,3R)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate

IUPAC Name

(2R,3R)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate

Melting Point

123-125°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3586 MSDS PDF

Info Sheet

R3586 Info Sheet PDF

References

Wu J, Tan Z, Pistolozzi M, et al. Rivastigmine-bambuterol hybrids as selective butyrylcholinesterase inhibitors. Molecules. 2023 Dec 22;29(1):72. PMID: 38202655.

Moriguchi S, Tagashira H, Sasaki Y, et al. CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment. J Neurochem. 2013 Oct 28. [Epub ahead of print]. PMID: 24164423.

Bailey JA, Ray B, Greig NH, et al. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One. 2011;6(7):e21954. PMID: 21799757.

Pollak Y, Gilboa A, Ben-Menachem O, et al. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Ann Neurol. 2005 May;57(5):741-5. PMID: 15852394.

Krall WJ, Sramek JJ, Cutler NR. Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease. Ann Pharmacother. 1999 Apr;33(4):441-50. PMID: 10332536.

Custom Order

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