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7-O-Desmethyl Rapamycin

Product ID D183734
Cas No. 151519-50-5
Purity ≥85%
Product Unit SizeCostQuantityStock
2.5 mg $572.30 In stock
5 mg $926.50 In stock
10 mg $1,580.50 In stock
25 mg $2,725.00 In stock
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Description

7-O-Desmethyl Rapamycin is an impurity of rapamycin. Rapamycin is a macrolide initially produced by Streptomyces that exhibits immunosuppressive and pro-fibrotic activities. Rapamycin inhibits mTOR by binding FKBP12 and forming a complex that binds directly to mTOR; it is clinically used to prevent rejection in organ transplant patients. Rapamycin prevents IL-2-induced activation of T cells and B cells. Rapamycin also prevents IgA nephropathy, decreasing IgA deposition, inhibiting cell proliferation, and suppressing expression of α-SMA, type III collagen, PDGF, and TGF-β1. Additionally, rapamycin increases connective tissue growth factor levels in epithelial cells.

Product Info

Cas No.

151519-50-5

Purity

≥85%

Formula

C50H77NO13

Formula Wt.

900.15

Chemical Name

7-O-Desmethyl Rapamycin

IUPAC Name

(1R,9S,12S,15R,16E,18R,19S,21S,23R,24E,26E,28E,30S,32R,35R)-1,18,30-Trihydroxy-12-{(2R)-1-[(1S,3S,4R)-4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-a zatricyclo[30.3.1.0~4,9~]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

Synonym

7-O-Demethyl Sirolimus; 7-O-demethyl rapamycin; 7-O-Desmethyl Sirolimus; Novolimus

Shipping and Storage

Store Temp

-80°C

Ship Temp

Ambient

Downloads

MSDS

D183734 MSDS PDF

Info Sheet

D183734 Info Sheet PDF

References

Klintmalm GB, Nashan B. The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence. J Transplant. 2014;2014:845438. PMID: 24719752.

Tian J, Wang Y, Zhou X, et al. Rapamycin slows IgA nephropathy progression in the rat. Am J Nephrol. 2014;39(3):218-29. PMID: 24603476.

Xu X, Wan X, Geng J, et al. Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase. Exp Biol Med (Maywood). 2013 Sep;238(9):1082-94. PMID: 23986222.

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