• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
N-(4-Hydroxyphenyl)retinamide

N-(4-Hydroxyphenyl)retinamide

Product ID H9613
Cas No. 65646-68-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $183.60 In stock
10 mg $337.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fenretinide is a synthetic retinol/vitamin A analog that binds RBP4 and exhibits anti-diabetic, antihypertensive, an anticancer chemotherapeutic activities. Fenretinide increases ceramide levels in vivo. In obese mice, fenretinide increases fat oxidation and decreases levels of total cholesterol and triglycerides, preventing fatty liver disease. Fenretinide also inhibits Des1, improving insulin sensitivity and normalizing glucose homeostasis in other animal models. Additionally, this compound induces caspase 3-dependent apoptosis in cancer cells and decrease tumor volume in animal models of lung cancer.

Product Info

Cas No.

65646-68-6

Purity

≥98%

Formula

C26H33NO2

Formula Wt.

391.55

IUPAC Name

(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6, 6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide

Synonym

Fenretinide, 4-HPR, Retinoic acid p-hydroxyanilide

Melting Point

173-175°C

Solubility

Soluble in DMSO (25mg/mL) or ethanol (25mg/mL).

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9613 MSDS PDF

Info Sheet

H9613 Info Sheet PDF

References

Durante S, Orienti I, Teti G, et al. Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model. Oncotarget. 2014 May 28. [Epub ahead of print]. PMID: 25015569.

Bikman BT, Guan Y, Shui G, et al. Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem. 2012 May 18;287(21):17426-37. PMID: 22474281.

Koh IU, Jun HS, Choi JS, et al. Fenretinide ameliorates insulin resistance and fatty liver in obese mice. Biol Pharm Bull. 2012;35(3):369-75. PMID: 22382323.

Guilbault C, De Sanctis JB, Wojewodka G, et al. Fenretinide corrects newly found ceramide deficiency in cystic fibrosis. Am J Respir Cell Mol Biol. 2008 Jan;38(1):47-56. PMID: 17656682.

Wu JM, DiPietrantonio AM, Hsieh TC. Mechanism of fenretinide (4-HPR)-induced cell death. Apoptosis. 2001 Oct;6(5):377-88. PMID: 11483862.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H1794

    Hexamethonium Bromide Hydrate

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • T2934

    Thiamphenicol Palmitate

    Chloramphenicol derivative; protein translation...

    ≥98%
  • B8248

    Bumetanide

    Loop diuretic; NKCC symporter and KCC2 co-trans...

    ≥98%
  • O938582

    41-Oxo-rapamycin

    Impurity of rapamycin

    ≥95%
  • Z4552

    ZLN005

    PPARγ coactivator-1α expression stimulator.

    ≥98%
  • P0268

    Parasin I

    Histone H2-derived antimicrobial peptide found ...

    ≥95%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.

    ≥98%
  • V0148

    Valproic Acid

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • C8069

    Curcumin

    Diarylheptanoid found in Zingiberaceae.

    ≥97% curcuminoid content
  • G0145

    Gallic Acid

    Phenol found in various plant sources, used to ...

    ≥98%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • P9671

    Pyrazinamide

    Nicotinamide analog prodrug; fatty acid synthet...

    ≥98%
  • T1652

    Teniposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥97%
  • T564092

    γ-Tocopherol

    Vitamin E component

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only