ZLN005 increases expression of PPAR-γ coactivator-1α (PGC-1α), exhibiting anti-diabetic activity. In animal models of diabetes, this compound increases activation of AMPK, stimulates fat oxidation, and improves glucose tolerance and insulin sensitivity.
| Cas No. | 49671-76-3 |
|---|---|
| Purity | ≥98% |
| Formula | C17H18N2 |
| Formula Wt. | 250.35 |
| IUPAC Name | 2-[4-(2-Methyl-2-propanyl)phenyl]-1H-benzimidazole |
| Solubility | DMSO 37 mg/mL Ethanol 2 mg/mL Water Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Zhang LN, Zhou HY, Fu YY, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307. PMID: 23250358.
