LKT Labs

Biochemicals for Life Science Research

Telmisartan

Product ID T1644
Cas No. 144701-48-4
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $129.60 In stock
100 mg $222.50 In stock
500 mg $648.30 In stock
Bulk Quote

Quicklinks

Description

Telmisartan is a long-acting antagonist at angiotensin II type 1 (AT II) receptors that is clinically used to treat hypertension. Telmisartan exhibits antihypertensive, anti-diabetic, anti-obesity, anti-inflammatory, and anti-hyperlipidemic activities. Telmisartan decreases levels of total cholesterol and LDL in vivo. Telmisartan also decreases weight gain and increases activity endurance and oxygen consumption in other animal models. This compound is also a selective modulator of PPARγ/δ, decreasing insulin, glucose, and triglyceride levels in high fat diet-fed rats. In endothelial cells, telmisartan decreases expression of MCP-1 and VCAM-1 and prevents activation of NF-κB.

Product Info

Cas No.

144701-48-4
Purity

≥98%
Formula

C33H30N4O2
Formula Wt.

514.63
Chemical Name

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
IUPAC Name

2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl] methyl]phenyl]benzoic acid
Synonym

BIBR 277, Micardis, Pritor
Melting Point

261-263°C
Solubility

Soluble in DMSO (1.2mg/mL). Insoluble in water. Chloroform.
Appearance

White to Off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T1644 MSDS PDF
Info Sheet

T1644 Info Sheet PDF

References

Xu S, Song H, Huang M, et al. Telmisartan inhibits the proinflammatory effects of homocysteine on human endothelial cells through activation of the peroxisome proliferator-activated receptor-δ pathway. Int J Mol Med. 2014 Sep;34(3):828-34. PMID: 24994548.

Sueta D, Koibuchi N, Hasegawa Y, et al. Telmisartan Exerts Sustained Blood Pressure Control and Reduces Blood Pressure Variability in Metabolic Syndrome by Inhibiting Sympathetic Activity. Am J Hypertens. 2014 May 28. [Epub ahead of print]. PMID: 24871627.

Feng X, Luo Z, Ma L, et al. Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-δ/AMPK pathway. J Cell Mol Med. 2011 Jul;15(7):1572-81. PMID: 20477906.

Inoue T, Taguchi I, Abe S, et al. Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan. J Clin Pharm Ther. 2011 Feb;36(1):103-10. PMID: 21198725.

Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension. 2004 May;43(5):993-1002. PMID: 15007034.

Okada M, Kosaka N, Hoshino Y, et al. Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats. Biol Pharm Bull. 2010;33(9):1517-1521. PMID: 20823567.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.