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Glycitein

Product ID G4798
Cas No. 40957-83-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $116.00 In stock
5 mg $190.90 In stock
10 mg $305.70 In stock
25 mg $629.80 In stock
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  • Description
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Description

Glycitein is an aglycone isoflavone found in soy and red clover; it exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. This compound also acts as a phytoestrogen. Glycitein inhibits generation of ROS, increases expression of heme oxygenase-1 (HO-1) and NADPH quinone reductase, and increases Nrf2-related antioxidative signaling. In vitro, glycitein downregulates expression of matrix metalloproteinases 3 and 9, preventing invasion of glioma cells. Additionally, this compound increases ERK1/2 activity and decreases cell proliferation in prostate cells. In aortic smooth muscle cells, glycitein inhibits DNA synthesis and cell proliferation, attenuating a pathology that occurs in atherosclerosis. In cellular models of Alzheimer’s disease, glycitein also binds to amyloid-β (Aβ) monomers, oligomers, and fibrils, destabilizing Aβ aggregates and preventing fibril assembly. Glycitein also affects bone formation, inhibiting osteoclast generation and decreasing expression of IL-6 and RANKL in bone marrow-derived osteoclasts.

Product Info

Cas No.

40957-83-3

Purity

≥98%

Formula

C16H12O5

Formula Wt.

284.26

Chemical Name

7-hydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one

IUPAC Name

7-hydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one

Appearance

Pale tan powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G4798 MSDS PDF

Info Sheet

G4798 Info Sheet PDF

References

Hirohata M, Ono K, Takasaki J, et al. Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. Biochim Biophys Acta. 2012 Aug;1822(8):1316-24. PMID: 22587837.

Park JS, Jung JS, Jeong YH, et al. Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. J Neurochem. 2011 Dec;119(5):909-19. PMID: 21781119.

Winzer M, Rauner M, Pietschmann P. Glycitein decreases the generation of murine osteoclasts and increases apoptosis. Wien Med Wochenschr. 2010 Sep;160(17-18):446-51. PMID: 20714813.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem. 2007 Aug;18(8):525-32. PMID: 17156992.

Pan W, Ikeda K, Takebe M, et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001 Apr;131(4):1154-8. PMID: 11285318.

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