Description
AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.
AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.
Cas No. | 118409-57-7 |
---|---|
Purity | ≥98% |
Formula | C10H6N2O2 |
Formula Wt. | 186.17 |
IUPAC Name | (3,4-Dihydroxybenzylidene)malononitrile |
Synonym | Tyrphostin A23 |
Solubility | DMSO 37 mg/mL Ethanol 37 mg/mL Water Insoluble |
Appearance | Yellow solid |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.
Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.
Triterpene sapogenin found in species of Panax;...
Synthetic fluorinated thiamphenicol analog; pro...
PKC and PKD activator, carcinogen.
Viral M2 proton channel blocker.
5-HT2 antagonist, SERT and NET inhibitor, hERG ...
Endogenous hormone and neurotransmitter involve...
FXR agonist.
Shellfish toxin produced by dinoflagellates and...
Fluoroquinolone, S-(-) isomer of ofloxacin; top...
Phytohormone
Flavonoid originally found in Silybum (milk thi...
Protease substrate.
Naturally occuring isothiocyanate found in broc...
Carotene pigment found in red and green fruits ...
Focal adhesion kinase (FAK) inhibitor.
Peptide, protease substrate.
ITC found in cruciferous vegetables.
Triterpene isolated Trypterigium wilfordii; HSP...
β-adrenergic agonist.
Alters membrane permeability and Ca2+ signaling...