Description
AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.
Product Info
| Cas No. | 118409-57-7 |
|---|---|
| Purity | ≥98% |
| Formula | C10H6N2O2 |
| Formula Wt. | 186.17 |
| IUPAC Name | (3,4-Dihydroxybenzylidene)malononitrile |
| Synonym | Tyrphostin A23 |
| Solubility | DMSO 37 mg/mL Ethanol 37 mg/mL Water Insoluble |
| Appearance | Yellow solid |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
|---|---|
| Info Sheet |
References
Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.
Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.