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Ginsenoside Rb3

Ginsenoside Rb3

Product ID G3554
Cas No. 68406-26-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $245.30 In stock
10 mg $449.10 In stock
25 mg $816.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginsenoside Rb3 is a triterpene saponin originally found in species of Panax (ginseng) that exhibits cardioprotective, antioxidative, antidepressant, and anti-diabetic activities. Ginsenoside Rb3 inhibits contractions in aortic rings and suppresses expression of ROS, NOX-2, and NOX-4, decreasing oxidative stress and improving endothelial function. In diabetic mice, ginsenoside Rb3 decreases blood glucose levels and improves oral glucose tolerance. Ginsenoside Rb3 also decreases immobility time in the forced swim, tail suspension, and learned helplessness tests. Additionally, this compound decreases levels of malondialdehyde and increases activity of superoxide dismutase, decreasing infarct size in animal models of myocardial ischemia/reperfusion.

Product Info

Cas No.

68406-26-8

Purity

≥98%

Formula

C53H90O22

Formula Wt.

1079.27

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4, 5-dihydroxy-6-(hydroxymethyl)-2-[[(10R,12S,14R)-12-hydroxy-4,4,10, 14-tetramethyl-17-[(E,2R)-6-methyl-2-[(2S,3R,4R,5S,6R)-3,4, 5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4, 5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxyoct-5-en-2-yl]-1,2,3,5,6,7, 8,9,11,12,13,15,16, 17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6- (hydroxymethyl)oxane-3,4,5-triol

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3554 MSDS PDF

Info Sheet

G3554 Info Sheet PDF

References

Wang Y, Dong J, Liu P, et al. Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats. Br J Pharmacol. 2014 Jul;171(13):3171-81. PMID: 24571453.

Bu QT, Zhang WY, Chen QC, et al. Anti-diabetic effect of ginsenoside Rb(3) in alloxan-induced diabetic mice. Med Chem. 2012 Sep;8(5):934-41. PMID: 22741793.

Cui J, Jiang L, Xiang H. Ginsenoside Rb3 exerts antidepressant-like effects in several animal models. J Psychopharmacol. 2012 May;26(5):697-713. PMID: 21948936.

Shi Y, Han B, Yu X, et al. Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats. Pharm Biol. 2011 Sep;49(9):900-6. PMID: 21591990.

Custom Order

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