Clozapine

Product ID C4757

Cas No. 5786-21-0

Purity ≥97%

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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Clozapine is an atypical antipsychotic that also exhibits some immunosuppressive activity. Clozapine is clinically used to treat mood disorders. Clozapine binds Kv1.1 channels, prolonging the QT interval and also causes granulocytosis, limiting its clinical use. Clozapine acts as an antagonist at M1/2/3/5 muscarinic acetylcholine receptors (mAChRs) and D2 receptors, a partial agonist at 5-HT1A receptors, and as a full agonist at M4 mAChRs. Additionally, clozapine binds 5-HT2/3/6/7 receptors, D4 receptors, α1/2 adrenergic receptors, and histamine H1 receptors. Clozapine also potentiates GABAergic neurotransmission.

Product Info

Cas No.	5786-21-0
Purity	≥97%
Formula	C₁₈H₁₉ClN₄
Formula Wt.	326.82
Chemical Name	8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine
IUPAC Name	3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym	Clozaril, Leponex
Melting Point	183-184°C
Solubility	Soluble in DMSO or dilute aqueous acid.
Appearance	Yellow crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C4757 MSDS PDF
Info Sheet	C4757 Info Sheet PDF

References

Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.