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INCB018424

Product ID I5210
Cas No. 941678-49-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $88.80 In stock
25 mg $291.00 In stock
50 mg $451.80 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

INCB018424 is an inhibitor of JAK1/2 that is clinically used to treat rheumatoid arthritis and myelofibrosis. INCB018424 exhibits anticancer, anti-inflammatory, and antiviral activities. In myeloma cells, INCB018424 inhibits cell growth. INCB018424 also inhibits in vitro infection by HIV-1, HIV-2, and SHIV by preventing viral replication in lymphocytes. In animal models of CCL4-induced hepatic injury, INCB018424 prevents inflammation by decreasing neutrophil and macrophage infiltration, suppressing activation of NF-κB, and limiting release of TNF-α, IL-10, and IL-1β.

Product Info

Cas No.

941678-49-5

Purity

≥98%

Formula

C17H18N6

Formula Wt.

306.37

IUPAC Name

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Synonym

Ruxolitinib

Solubility

DMSO 61 mg/mL (199.1 mM) Ethanol 61 mg/mL (199.1 mM) Water Insoluble

Appearance

Yellow to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I5210 MSDS PDF

Info Sheet

I5210 Info Sheet PDF

References

Springuel L, Hornakova T, Losdyck E, et al. Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors. Blood. 2014 Dec 18;124(26):3924-31. PMID: 25352124.

Hazem SH, Shaker ME, Ashamallah SA, et al. The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms. Chem Biol Interact. 2014 Sep 5;220:116-27. PMID: 24973641.

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro. Antimicrob Agents Chemother. 2014;58(4):1977-86. PMID: 24419350.

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