• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Chromomycin A3

Chromomycin A3

Product ID C2969
Cas No. 7059-24-7
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $90.30 In stock
5 mg $315.20 In stock
10 mg $563.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chromomycin A3 is an anthraquinone that exhibits antibacterial and anticancer chemotherapeutic activity. Chromomycin A3 binds Mg2+ and Zn2+ ions, and these complexes bind GC sequences in nucleosomal DNA; this inhibits DNA gyrase, RNA polymerase, and DNA transcription. Chromomycin inhibits growth of bacteria such as Bacillus, inhibits alcohol dehydrogenase, and suppresses tumor growth of breast cancer xenografts in animal models.

Product Info

Cas No.

7059-24-7

Purity

≥97%

Formula

C57H82O26

Formula Wt.

1183.2488

IUPAC Name

[6-[[6-[4-[4-(5-acetyloxy-4-hydroxy-4, 6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6- methyloxan-2-yl]oxy-7-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-4, 10-dihydroxy-3-methyl-5-oxo-7, 8-dihydro-6H-anthracen-2-yl]oxy]-4-(4-hydroxy-5-methoxy-6-methyloxan-2- yl)oxy-2-methyloxan-3-yl] acetate

Melting Point

182-186°C

Appearance

Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C2969 MSDS PDF

Info Sheet

C2969 Info Sheet PDF

References

Devi PG, Chakraborty PK, Dasgupta D. Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3. J Biol Inorg Chem. 2009 Mar;14(3):347-59. PMID: 19034537.

Mir MA, Dasgupta D. Association of the anticancer antibiotic chromomycin A(3) with the nucleosome: role of core histone tail domains in the binding process. Biochemistry. 2001 Sep 25;40(38):11578-85. PMID: 11560508.

Simon H, Wittig B, Zimmer C. Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase. FEBS Lett. 1994 Oct 10;353(1):79-83. PMID: 7926028.

Inoue K, Fujimoto S, Ogawa M. Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Cancer Chemother Pharmacol. 1983;10(3):182-6. PMID: 6305523.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • H014458

    Halometasone

    Glucocorticoid

    ≥98%
  • P691320

    PRI-724

    Wnt/beta-catenin/CBP inhibitor

    ≥98%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • N859610

    NVP-HDM201

    HDM2 inhibitor

    ≥99%
  • V0244

    Valganciclovir Hydrochloride

    Nucleoside (deoxyguanosine) analog, ganciclovir...

    ≥98%
  • S8248

    Sulfamethoxazole

    Sulfonamide; PABA inhibitor.

    ≥98%
  • A4402

    L-Alaninol

    Amino acid alcohol.

    ≥98%
  • G3557

    Ginsenoside Rh1

    Triterpene saponin found in species of Panax.

    ≥77%
  • A990144

    AZD4320

    Inhibitor of Bcl-2 and Bcl-xL

    ≥99%
  • B1876

    Betamethasone

    Steroid; glucocorticoid agonist.

    ≥98%
  • F4883

    Flutriafol

    Triazole; demethylation inhibitor, NMDA agonist...

    ≥97%
  • H1862

    Heptaplatin

    Pt-based DNA cross-linker.

    ≥98%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy ho...

    ≥98%
  • C0278

    (+)-Catechin

    Flavanol originally found in Camilla (green tea...

    ≥99%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • I0481

    Ibuprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only