• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Donepezil Hydrochloride

Donepezil Hydrochloride

Product ID D5753
Cas No. 120011-70-3
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $89.70 In stock
100 mg $280.60 In stock
500 mg $1,010.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Donepezil is an acetylcholinesterase (AChE) inhibitor that is clinically used to treat Alzheimer’s disease. Donepezil displays neuroprotective, cognition enhancing, cardioprotective, and anti-inflammatory activities. In animal models, donepezil improves memory and learning ability. In vitro, donepezil downregulates expression of the NR1 subunit of NMDA receptors, inhibiting glutamate-mediated Ca2+ entry into cells; this mechanism is thought to be dependent on donepezil activity on α7 nicotinic acetylcholine receptors (nAChRs). Additionally, this compound inhibits glycogen synthase kinase 3 (GSK3) and activates PI3K/Akt signaling, helping to prevent amyloid-β (Aβ) toxicity. Donepezil also binds to σ1 receptors. In animal models of congestive heart failure, donepezil decreases left ventricular end diastolic pressure, increases left ventricular contractility, decreases left ventricular expression of brain natriuretic peptide (BNP), and decreases heart weight, resulting in greater survival rates.

Product Info

Cas No.

120011-70-3

Purity

≥98%

Formula

C24H29NO3 • HCl

Formula Wt.

415.95

Chemical Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

IUPAC Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2, 3-dihydroinden-1-one;hydrochloride

Synonym

Aricept, BNAG

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5753 MSDS PDF

Info Sheet

D5753 Info Sheet PDF

References

Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.

    ≥98%
  • G0247

    2″O-Galloylhyperin

    Flavonoid glycoside found in Pyrola.

    ≥98%
  • K9200

    KX1-004

    Indole; Src inhibitor.

    ≥98%
  • G681019

    Grapiprant

    EP4 receptor antagonist

    ≥98%
  • N5072

    NMS-1286937

    PLK1 inhibitor.

    ≥98%
  • D3431

    3,4-Dihydroxyphenyl Ethanol

    Polyphenol found in olive oil, antioxidant.

    ≥95%
  • A985128

    AZD-7648

    DNA-PK inhibitor.

    ≥98%
  • W9602

    WY-14643

    A peroxisome proliferator-activated receptor ag...

    ≥98%
  • C5773

    Cortistatin-14

    Endogenous neuropeptide, somatostatin analog; s...

    ≥95%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • S5722

    Sofosbuvir

    Viral RNA polymerase inhibitor.

    ≥98%
  • M1845

    Melitracen Hydrochloride

    Tricyclic antidepressant; potential D1/2 antago...

    ≥99%
  • G7242

    GSK-690693

    Akt inhibitor.

    ≥99%
  • J0379

    Jatrorrhizine Chloride

    Alkaloid compound originally found in Corydalis...

    ≥95%
  • B6935

    Brivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • A4445

    Allopurinol

    Purine (hypoxanthine) analog; xanthine oxidase ...

    ≥98%
  • P2516

    S-(N-Phenylbutylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa...

    ≥91%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only