LKT Labs

Biochemicals for Life Science Research

Gonadorelin Acetate

Gonadorelin Acetate

Product ID G5752
Cas No. 71447-49-9
Purity ≥95%
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Description

Gonadorelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH). Gonadorelin acts as an agonist at the GnRH/LHRH receptor, inducing release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This hormone is clinically used to treat endometriosis. Gonadorelin exhibits anti-androgen and anticancer chemotherapeutic activities. In vitro and in vivo, gonadorelin inhibits testosterone activation of androgen receptors. Additionally, gonadorelin increases proliferation of normal cells but inhibits proliferation of prostate cancer cells through a mechanism that involved activation of the ryanodine receptor and increases in intracellular Ca2+ levels.

Product Info

Cas No.

71447-49-9

Purity

≥95%

Formula

C55H75N17O13 • 2(C2H4O2)

Formula Wt.

1302.59

IUPAC Name

acetic acid;N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;hydrate

Synonym

Luteinizing hormone-releasing factor acetate, LH-RH

Solubility

Soluble in water, methanol.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

G5752 Info Sheet PDF

References

Maudsley S, Davidson L, Pawson AJ, et al. Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2006;84(5):285-300. PMID: 17202804.

Maiti K, Oh DY, Moon JS, et al. Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death. J Clin Endocrinol Metab. 2005 Jul;90(7):4287-98. PMID: 15870130.

Enomoto M, Park MK. GnRH as a cell proliferation regulator: mechanism of action and evolutionary implications. Zoolog Sci. 2004 Oct;21(10):1005-13. PMID: 15514469.

Shalev E, Leung PC. Gonadotropin-releasing hormone and reproductive medicine. J Obstet Gynaecol Can. 2003 Feb;25(2):98-113. PMID: 12577127.

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